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Article

A Dam methylation mutant of Klebsiella pneumoniae is partially attenuated.

FEMS microbiology letters - 1 Mar 2007

Mehling Joanna S, Lavender Heather, Clegg Steven

Abstract excerpt

In Klebsiella pneumoniae, a chromosomal insertion mutation was constructed in the dam gene, which encodes DNA adenine methylase (Dam), resulting in a mutant unable to methylate specific nucleotides. In some bacteria, the Dam methylase has been shown to play an important role in virulence gene regulation as well as in methyl-directed mismatch repair and the regulation of replication initiation. Disruption of the...

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Identifiers

PMID: 17328745
DOI: 10.1111/j.1574-6968.2006.00581.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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