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Article

Methylome-dependent transformation of emm1 group A streptococci.

mBio - 31 Aug 2023

Alves Joana, Rand Joshua D, Johnston Alix B E, Bowen Connor, Lynskey Nicola N

Abstract excerpt

Genetic intractability presents a fundamental barrier to the manipulation of bacteria, hindering advancements in microbiological research. Group A Streptococcus (GAS), a lethal human pathogen currently associated with an unprecedented surge of infections worldwide, exhibits poor genetic tractability attributed to the activity of a conserved type 1 restriction modification system (RMS). RMS detect and cleave...

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Identifiers

PMID: 37427929
DOI: 10.1128/mbio.00798-23
PMCID: PMC10470502

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