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Article

Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.

European journal of clinical pharmacology - 1 Aug 2006

Tarantino Giovanni, Conca Paolo, Capone Domenico, Gentile Antonio, Polichetti Giuliano, Basile Vincenzo

Abstract excerpt

BACKGROUND AND AIMS: Systemic caffeine clearance is considered the gold standard for phenotyping cytochrome P450 1A2 in epidemiological studies, and has been recommended for the non-invasive assessment of liver function in chronic liver disease. Our aim was to find a valid, simple and reliable alternative to this method, and therefore focused our attention on the measurement of an unique salivary caffeine...

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Source

Identifiers

PMID: 16841221
DOI: 10.1007/s00228-006-0146-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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