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Article

Genes, environment and the value of prospective cohort studies.

Nature reviews. Genetics - 1 Oct 2006

Manolio Teri A, Bailey-Wilson Joan E, Collins Francis S

Abstract excerpt

Case-control studies have many advantages for identifying disease-related genes, but are limited in their ability to detect gene-environment interactions. The prospective cohort design provides a valuable complement to case-control studies. Although it has disadvantages in duration and cost, it has important strengths in characterizing exposures and risk factors before disease onset, which reduces important...

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PMID: 16983377
DOI: 10.1038/nrg1919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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