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Article

Further development of the case-only design for assessing gene-environment interaction: evaluation of and adjustment for bias.

International journal of epidemiology - 1 Oct 2004

Gatto Nicolle M, Campbell Ulka B, Rundle Andrew G, Ahsan Habibul

Abstract excerpt

BACKGROUND: The case-only study for investigating gene-environment interactions provides increased statistical efficiency over case-control analyses. This design has been criticized for being susceptible to bias arising from non-independence between the genetic and environmental factors in the population. Given that independence is critical to the validity of case-only estimates of interaction, researchers...

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Identifiers

PMID: 15358745
DOI: 10.1093/ije/dyh306

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