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Hypoxia Regulates Bone Morphogenetic Protein Signaling Through C-Terminal–Binding Protein 1

14 Jul 2006

Abstract excerpt

Bone morphogenetic protein receptor 2 (BMPR2) mutations have been linked to familial pulmonary arterial hypertension (PAH), but the molecular pathways leading to this severe pathology remain poorly characterized. We report that hypoxia, a paramount stimulus for the development of pulmonary hypertension, suppresses the expression of inhibitor of differentiation 1 (Id1), a downstream target of the BMPR2 pathway, in...

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PMID: 16840720
DOI: 10.1161/01.res.0000237021.65103.24

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