Article
Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension.
American journal of respiratory cell and molecular biology - 1 Jun 2014
Li Molong, Vattulainen Sanna, Aho Joonas, Orcholski Marc, Rojas Vanessa, Yuan Ke, Helenius Mikko, Taimen Pekka, Myllykangas Samuel, De Jesus Perez Vinicio, Koskenvuo Juha W, Alastalo Tero-Pekka
Abstract excerpt
Occlusive vasculopathy with intimal hyperplasia and plexogenic arteriopathy are severe histopathological changes characteristic of pulmonary arterial hypertension (PAH). Although a phenotypic switch in pulmonary endothelial cells (ECs) has been suggested to play a critical role in the formation of occlusive lesions, the pathobiology of this process is poorly understood. The goal of this study was to identify...
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