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Article

Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus.

Experimental dermatology - 1 Apr 2016

Birner Peter, Heider Susanne, Petzelbauer Peter, Wolf Peter, Kornauth Christoph, Kuroll Madeleine, Merkel Olaf, Steiner Günter, Kishimoto Tadamitsu, Rose-John Stefan, Soleiman Afschin, Moriggl Richard, Kenner Lukas

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease, characterized by antinuclear autoantibodies (ANA) and immunocomplexes, commonly affecting kidneys, skin, heart, lung or even the brain. We have shown that JunB(Δep) mice develop a SLE phenotype linked to increased epidermal Interleukin (IL)-6 secretion. Blocking of IL-6 receptor alpha (IL-6Rα) is considered as therapeutic strategy for the treatment of...

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Identifiers

PMID: 26739431
DOI: 10.1111/exd.12934
PMCID: PMC4982049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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