Article
S2'-subsite variations between human and mouse enzymes (plasmin, factor XIa, kallikrein) elucidate inhibition differences by tissue factor pathway inhibitor -2 domain1-wild-type, Leu17Arg-mutant and aprotinin.
Journal of thrombosis and haemostasis : JTH - 1 Dec 2016
Vadivel K, Kumar Y, Ogueli G I, Ponnuraj S M, Wongkongkathep P, Loo J A, Bajaj M S, Bajaj S P
Abstract excerpt
Essentials Current antifibrinolytics - aminocaproic acid and tranexamic acid-can cause seizures or renal injury. KD1L17R -KT , aprotinin and tranexamic acid were tested in a modified mouse tail-amputation model. S2'-subsite variations between human and mouse factor XIa result in vastly different inhibition profiles. KD1L17R -KT reduces blood loss and D-dimer levels in mouse with unobserved seizures or renal...
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