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Article

Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock.

Surgery - 1 Aug 2015

Moore Hunter B, Moore Ernest E, Lawson Peter J, Gonzalez Eduardo, Fragoso Miguel, Morton Alex P, Gamboni Fabia, Chapman Michael P, Sauaia Angela, Banerjee Anirban, Silliman Christopher C

Abstract excerpt

INTRODUCTION: Systemic hyperfibrinolysis (accelerated clot degradation) and fibrinolysis shutdown (impaired clot degradation) are associated with increased mortality compared with physiologic fibrinolysis after trauma. Animal models have not reproduced these changes. We hypothesize rodents have a shutdown phenotype that require an exogenous profibrinolytic to differentiate mechanisms that promote or inhibit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25979440
DOI: 10.1016/j.surg.2015.04.008
PMCID: PMC4492895

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