Article
A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels.
Blood - 1 May 2007
Viel Kevin R, Machiah Deepa K, Warren Diane M, Khachidze Manana, Buil Alfonso, Fernstrom Karl, Souto Juan C, Peralta Juan M, Smith Todd, Blangero John, Porter Sandra, Warren Stephen T, Fontcuberta Jordi, Soria Jose M, Flanders W Dana, Almasy Laura, Howard Tom E
Abstract excerpt
Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to contribute to the broad population variability observed for this trait. Because less than 2.5% of the structural FVIII gene (F8) has been examined previously, we...
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