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Article

Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease.

Seminars in thrombosis and hemostasis - 1 Mar 2024

Park Jin K, Brake Marisa A, Schulman Sol

Abstract excerpt

Tissue factor (TF) is the primary initiator of blood coagulation in humans. As improper intravascular TF expression and procoagulant activity underlie numerous thrombotic disorders, there has been longstanding interest in the contribution of heritable genetic variation in F3, the gene encoding TF, to human disease. This review seeks to comprehensively and critically synthesize small case-control studies focused...

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PMID: 37201535
DOI: 10.1055/s-0043-1769079

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