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Article

The regulation of HIV-1 transcription: Molecular targets for chemotherapeutic intervention

1 Jan 2006

Abstract excerpt

The regulation of transcription of the human immunodeficiency virus (HIV) is a complex event that requires the cooperative action of both viral and cellular components. In latently infected resting CD4(+) T cells HIV-1 transcription seems to be repressed by deacetylation events mediated by histone deacetylases (HDACs). Upon reactivation of HIV-1 from latency, HDACs are displaced in response to the recruitment of...

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PMID: 16838299
DOI: 10.1002/med.20081

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