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Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control Tat-activated transcription and latency

2023-11-14

Abstract excerpt

The human immunodeficiency virus (HIV) integrates into the host genome forming latent cellular reservoirs that are an obstacle for cure or remission strategies. Viral transcription is the first step in the control of latency and depends upon the hijacking of the host cell RNA polymerase II (Pol II) machinery by the 5’ HIV LTR. Consequently, “block and lock” or “shock and kill” strategies for an HIV cure depend upo...

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Identifiers and source

Literature Corpus work
9295e0c6-4952-5e4e-8c4f-e477661b3f97
DOI
10.1101/2023.11.14.567009
Open publication

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Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control Tat-activated transcription and latencyDOI 10.1101/2023.11.14.567009
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