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Article

Structural constraints and mutational bias in the evolutionary restoration of a severe deletion in RNA phage MS2.

Journal of molecular evolution - 1 Sept 2006

Licis Normunds, van Duin Jan

Abstract excerpt

A 4-nucleotide (nt) deletion was made in the 36-nt-long intercistronic region separating the coat and replicase genes of the single-stranded RNA phage MS2. This region is the focus of several RNA structures conferring high fitness. One such element is the operator hairpin, which, in the course of infection, will bind a coat-protein dimer, thereby precluding further replicase synthesis and initiating...

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PMID: 16838216
DOI: 10.1007/s00239-005-0012-8

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