Article
Effect of deleterious mutation-accumulation on the fitness of RNA bacteriophage MS2.
Evolution; international journal of organic evolution - 1 Apr 2000
de la Peña M, Elena S F, Moya A
Abstract excerpt
RNA viruses show the highest mutation rate in nature. It has been extensively demonstrated that, in the absence of purifying selection, RNA viruses accumulate deleterious mutations at a high rate. However, the parameters describing this accumulation are, in general, poorly understood. The present study reports evidences for fitness declines by the accumulation of deleterious mutations in the bacteriophage MS2. We...
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