Article
Payoffs, not tradeoffs, in the adaptation of a virus to ostensibly conflicting selective pressures.
PLoS genetics - 1 Oct 2014
McGee Lindsey W, Aitchison Erick W, Caudle S Brian, Morrison Anneliese J, Zheng Lianqing, Yang Wei, Rokyta Darin R
Abstract excerpt
The genetic architecture of many phenotypic traits is such that genes often contribute to multiple traits, and mutations in these genes can therefore affect multiple phenotypes. These pleiotropic interactions often manifest as tradeoffs between traits where improvement in one property entails a cost in another. The life cycles of many pathogens include periods of growth within a host punctuated with transmission...
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