Article
Association study of promoter polymorphisms within the NOS3 gene and allergic diseases.
International archives of allergy and immunology - 1 Jan 2006
Holla Lydie Izakovicova, Stejskalova Andrea, Znojil Vladimír, Vasku Anna
Abstract excerpt
BACKGROUND: Nitric oxide (NO) is an important mediator of physiologic and pathologic processes in the airways. On this basis, we hypothesized that polymorphisms in the NOS3 gene could be associated with the disease process. METHODS: Two promoter variants (-786C/T and -691C/T) were examined in a Caucasian Czech population of allergic patients [n = 671, with a subgroup of asthmatics (n = 305)] and healthy controls...
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