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Article

CRL4<sup>Cdt2</sup>

14 Jan 2011

Abstract excerpt

Polyubiquitin-mediated degradation of proteins plays an essential role in various physiological processes including cell cycle progression, transcription and DNA replication and repair. Increasing evidence supports a vital role for the E3 ubiquitin ligase cullin-4, in conjunction with the substrate recognition factor Cdt2 (CRL4Cdt2), for the degradation of multiple cell cycle-regulated proteins to prevent genomic...

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PMID: 21212733
DOI: 10.4161/cc.10.2.14530

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