Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decapentaplegic-responsive silencers contain overlapping mad-binding sites.

The Journal of biological chemistry - 1 Sept 2006

Gao Sheng, Laughon Allen

Abstract excerpt

Smad proteins regulate transcription in response to transforming growth factor-beta signaling pathways by binding to two distinct types of DNA sites. The sequence GTCT is recognized by all receptor-activated Smads and by Smad4. The subset of Smads that responds to bone morphogenetic protein signaling recognizes a distinct class of GC-rich sites in addition to GTCT. Recent work has shown that Drosophila Mad...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Gene Silencing

Share to Models, Molecular

Share to Plasmids

Share to Repressor Proteins

Source

Identifiers

PMID: 16829514
DOI: 10.1074/jbc.M603371200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decapentaplegic-responsive silencers contain overlapping mad-binding sites.PMID 16829514Read ↗

Dpp-responsive silencers are bound by a trimeric Mad-Medea complex.Semantic proximity Read ↗

Characterization of a bone morphogenetic protein-responsive Smad-binding element.Semantic proximity Read ↗

Taking the message to the nucleus: MAD protein as a mediator of bone morphogenetic protein signaling.Semantic proximity Read ↗

Structure of Gremlin-1 and analysis of its interaction with BMP-2.Semantic proximity Read ↗

An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*.Semantic proximity Read ↗

Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4Semantic proximity Read ↗

Characterization of Medea, a gene required for maximal function of the Drosophila BMP homolog Decapentaplegic.Semantic proximity Read ↗

The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein.Semantic proximity Read ↗

Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif.Semantic proximity Read ↗

Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition.Semantic proximity Read ↗

Structural basis for the functional difference between Smad2 and Smad3 in FAST-2 (forkhead activin signal transducer-2)-mediated transcription.Semantic proximity Read ↗

Structure-function relationship of inhibitory Smads: Structural flexibility contributes to functional divergence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.