Article
Structure of Gremlin-1 and analysis of its interaction with BMP-2.
The Biochemical journal - 1 Jun 2016
Kišonaitė Miglė, Wang Xuelu, Hyvönen Marko
Abstract excerpt
Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β (TGF-β) signalling family and has a very broad biological role in development. Its signalling is regulated by many effectors: transmembrane proteins, membrane-attached proteins and soluble secreted antagonists such as Gremlin-1. Very little is known about the molecular mechanism by which Gremlin-1 and other DAN (differential...
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