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Article

Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif.

The Biochemical journal - 8 Mar 2017

Kattamuri Chandramohan, Nolan Kristof, Thompson Thomas B

Abstract excerpt

Bone morphogenetic proteins (BMPs) are regulated by extracellular antagonists of the DAN (differential screening-selected gene aberrative in neuroblastoma) family. Similar to the BMP ligands, certain DAN family members have been shown to interact with heparin and heparan sulfate (HS). Structural studies of DAN family members Gremlin-1 and Gremlin-2 (Grem2) have revealed a dimeric growth factor-like fold where a...

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Identifiers

PMID: 28104757
DOI: 10.1042/BCJ20161050
PMCID: PMC5510646

Genes

BMP2

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