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Article

An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*.

The Journal of biological chemistry - 22 Jun 2001

Liberati N T, Moniwa M, Borton A J, Davie J R, Wang X F

Abstract excerpt

The Smads are a family of sequence-specific DNA-binding proteins that modulate transcription in response to transforming growth factor beta (TGFbeta) by recruiting transcriptional activators like the histone acetyltransferase, p300/CBP, or repressors like the histone deacetylase, HDAC1, to TGFbeta target genes. The association of Smads and HDAC1 is mediated in part by direct binding of Smads to the...

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Share to Histone Deacetylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Smad3 Protein

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Source

Identifiers

PMID: 11306568
DOI: 10.1074/jbc.M010778200

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*.PMID 11306568Read ↗

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