Hypothermia Is a Potential New Therapy for a Subset of Tumors with Mutant p53.

Abstract excerpt

The tumor suppressor p53 gene is mutated in approximately 50% of all human tumors. Many tumor-associated mutant p53 proteins misfold into a common, denatured conformation and accumulate to high levels in human tumors. In such tumors, these mutant forms of p53 provide a "gain of function" to promote tumor progression. Therefore, targeting mutant p53 has become an attractive approach for cancer therapy. In this...

Topics

• Animals
• Humans
• Hypothermia
• Mice
• Mutation
• Neoplasms
• Temperature
• Tumor Suppressor Protein p53