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Article

PADI4 haplotypes in association with RA Mexican patients, a new prospect for antigen modulation.

Clinical & developmental immunology - 1 Jan 2013

Zavala-Cerna Maria Guadalupe, Gonzalez-Montoya Norma Guadalupe, Nava Arnulfo, Gamez-Nava Jorge I, Moran-Moguel Maria Cristina, Rosales-Gomez Roberto Carlos, Gutierrez-Rubio Susan Andrea, Sanchez-Corona Jose, Gonzalez-Lopez Laura, Davalos-Rodriguez Ingrid Patricia, Salazar-Paramo Mario

Abstract excerpt

Peptidyl arginine deiminase IV (PAD 4) is the responsible enzyme for a posttranslational modification called citrullination, originating the antigenic determinant recognized by anti-cyclic citrullinated peptide antibodies (ACPA). Four SNPs (single nucleotide polymorphisms) have been described in PADI4 gene to form a susceptibility haplotype for rheumatoid arthritis (RA); nevertheless, results in association...

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Source

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Identifiers

PMID: 24454473
DOI: 10.1155/2013/383681
PMCID: PMC3881379

Genes

PADI4

Provenance

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PADI4 haplotypes in association with RA Mexican patients, a new prospect for antigen modulation.PMID 24454473Read ↗

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