Article
Cytidine is a novel substrate for wild-type concentrative nucleoside transporter 2.
Biochemical and biophysical research communications - 25 Aug 2006
Nagai Katsuhito, Nagasawa Kazuki, Koma Mineto, Hotta Ayumi, Fujimoto Sadaki
Abstract excerpt
Nucleoside transporter (NT) plays key roles in the physiology of nucleosides and the pharmacology of its analogues in mammals. We previously cloned Na+/nucleoside cotransporter CNT2 from mouse M5076 ovarian sarcoma cells, the peptide encoded by it differing from that by the previously reported mouse CNT2 in five substitutions, and observed that the transporter can take up cytidine, like CNT1 and CNT3. In the...
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