Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY)

20 Oct 2020

Abstract excerpt

The Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY) in the liver delivers citrate from the blood into hepatocytes. As citrate is a key metabolite and regulator of multiple biochemical pathways, deletion of Slc13a5 in mice protects against diet-induced obesity, diabetes, and metabolic syndrome. Silencing the transporter suppresses hepatocellular carcinoma. Therefore, selective blockers of NaCT hold the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Ion Transport and Channel Regulation
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33079129
DOI: 10.1042/bcj20200592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY)PMID 33079129Read ↗

Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors.Semantic proximity Read ↗

Structure and inhibition mechanism of the human citrate transporter NaCT.Semantic proximity Read ↗

Functional Distinction between Human and Mouse Sodium-Coupled Citrate Transporters and Its Biologic Significance: An Attempt for Structural Basis Using a Homology Modeling ApproachSemantic proximity Read ↗

Targeting an allosteric binding site in the citrate transporter NaCT (SLC13A5)Semantic proximity Read ↗

A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects.Semantic proximity Read ↗

Role of Sodium dependent SLC13 transporter and its inhibitors in various metabolic disordersSemantic proximity Read ↗

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood-brain barrier.Semantic proximity Read ↗

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell linesSemantic proximity Read ↗

Plasma Membrane Na⁺-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy.Semantic proximity Read ↗

Analysis of naturally occurring mutations in the human uptake transporter NaCT important for bone and brain development and energy metabolism.Semantic proximity Read ↗

A cell-based method to assess the activity of the human sodium-coupled citrate transporterSemantic proximity Read ↗

Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.