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Article

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.

American journal of human genetics - 1 Aug 2006

Wallace Chris, Xue Ming-Zhan, Newhouse Stephen J, Marcano Ana Carolina B, Onipinla Abiodun K, Burke Beverley, Gungadoo Johannie, Dobson Richard J, Brown Morris, Connell John M, Dominiczak Anna, Lathrop G Mark, Webster John, Farrall Martin, Mein Charles, Samani Nilesh J, Caulfield Mark J, Clayton David G, Munroe Patricia B

Abstract excerpt

Identification of the genetic influences on human essential hypertension and other complex diseases has proved difficult, partly because of genetic heterogeneity. In many complex-trait resources, additional phenotypic data have been collected, allowing comorbid intermediary phenotypes to be used to characterize more genetically homogeneous subsets. The traditional approach to analyzing covariate-defined subsets...

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Identifiers

PMID: 16826522
DOI: 10.1086/506370
PMCID: PMC1559504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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