Article
Genetic control of postoperative systemic inflammatory reaction and pulmonary and renal complications after coronary artery surgery.
The Journal of thoracic and cardiovascular surgery - 1 Oct 2003
Gaudino Mario, Di Castelnuovo Augusto, Zamparelli Roberto, Andreotti Felicita, Burzotta Francesco, Iacoviello Licia, Glieca Franco, Alessandrini Francesco, Nasso Giuseppe, Donati Maria Benedetta, Maseri Attilio, Schiavello Rocco, Possati Gianfederico
Abstract excerpt
BACKGROUND: Although some data suggest that the individual genetic predisposition for developing major or minor degrees of postoperative systemic inflammatory reaction may influence postoperative morbidity, this hypothesis has not been clinically tested to date. Methods and results The -174 G/C polymorphism of the promoter of the interleukin 6 gene was determined preoperatively in 111 consecutive patients...
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