Article
Interleukin 6 G-174C polymorphism influences outcome following coronary revascularization surgery.
The heart surgery forum - 1 Jan 2005
Bittar Mohamad N, Carey John A, Barnard James, Fildes James E, Pravica Vera, Yonan Nizar, Hutchinson Ian V
Abstract excerpt
BACKGROUND: Levels of the proinflammatory cytokine interleukin 6 (IL-6) increase after surgery. The functional polymorphism in the IL-6 promoter region, G-174C, is associated with an increased risk of coronary heart disease. We investigated the genetic predisposition in IL-6 response to coronary revascularization and studied the association between the G-174C polymorphism, IL-6 levels, and clinical outcomes of...
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