Article
Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer.
Genetics and molecular research : GMR - 30 Jun 2006
Clarizia Alessandra D, Bastos-Rodrigues Luciana, Pena Heloísa B, Anacleto Charles, Rossi Benedito, Soares Fernando A, Lopes Ademar, Rocha José Cláudio C, Caballero Otávia, Camargo Anamaria, Simpson Andrew J G, Pena Sérgio D J
Abstract excerpt
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Considering that methylation abnormalities appear to be important for the pathogenesis of CRC,...
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