Article
Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population.
Genetics and molecular research : GMR - 21 Jun 2011
Sameer A S, Shah Z A, Nissar S, Mudassar S, Siddiqi M A
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T...
Topics
- Colorectal Neoplasms
- Female
- Genetic Predisposition to Disease
- Humans
- India
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Risk Factors