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Article

MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Wettergren Yvonne, Odin Elisabeth, Carlsson Göran, Gustavsson Bengt

Abstract excerpt

We recently analyzed the hypermethylation status of the p16INK4a (p16) gene promoter in normal-appearing mucosa obtained from patients with colorectal cancer. Hypermethylation of p16 was associated with reduced survival of these patients. In the present study, germ line polymorphisms in the folate- and methyl-associated genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR) and methionine...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Intestinal Mucosa

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Open in PubMed Open full text

Identifiers

PMID: 20549016
DOI: 10.2119/molmed.2009.00156
PMCID: PMC2935958

Genes

MTRR
MTHFR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer.PMID 20549016Read ↗

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