Article
Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in chronic liver diseases? Interim results of a large case-control study.
Journal of pediatric gastroenterology and nutrition - 1 Jul 2006
Regev Arie, Guaqueta Constanza, Molina Enrique G, Conrad Andrew, Mishra Vishnu, Brantly Mark L, Torres Maria, De Medina Maria, Tzakis Andreas G, Schiff Eugene R
Abstract excerpt
BACKGROUND: The role of the heterozygous PiZ state of alpha-1 antitrypsin deficiency (alpha1ATD) in the pathogenesis of chronic liver disease (LD) is still a matter of controversy. AIM: To determine the prevalence of alpha1ATD heterozygote states in a large population of patients with established LD compared with individuals with no LD, and to determine whether the prevalence of PiZ is increased in patients with...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
- Case-Control Studies
- Chronic Disease
- Cross-Sectional Studies
- Female
- Florida
- Gene Frequency
- Hepacivirus
- Heterozygote
- Humans