Pulmonary and Hepatic Outcomes in Intermediate Alpha-1 Antitrypsin Deficiency: A TriNetX Database Analysis

Abstract excerpt

<h4>Background: </h4> Alpha-1 antitrypsin deficiency (A1ATD) is a hereditary disorder affecting approximately 1 in 2,000 to 5,000 individuals of European ancestry. While severe deficiency (PiZZ genotype) is well-characterized, the clinical significance of relatively intermediate deficiency states (serum A1AT 40-80 mg/dL), predominantly comprising PiSZ, PiMZ, and PiSS genotypes, remains poorly defined. This study a...

Topics

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• alpha 1-Antitrypsin
• alpha 1-Antitrypsin Deficiency
• Cost of Illness
• Genotype
• Peptidase Inhibition and Analysis
• Protease and Inhibitor Mechanisms
• Pulmonary Disease, Chronic Obstructive
• Pulmonary Emphysema

Identifiers and source

Literature Corpus work

b0d8d9a2-7877-581f-880d-99926afec5db

DOI

10.20944/preprints202606.0117.v1