Article
Clinical and histologic features of adults with alpha-1 antitrypsin deficiency in a non-cirrhotic cohort.
Journal of hepatology - 1 Dec 2018
Clark Virginia C, Marek George, Liu Chen, Collinsworth Amy, Shuster Jonathan, Kurtz Tracie, Nolte Joanna, Brantly Mark
Abstract excerpt
BACKGROUND & AIMS: Alpha-1 antitrypsin deficiency (AATD) is an uncommonly recognized cause of liver disease in adults, with descriptions of its natural history limited to case series and patient-reported data from disease registries. Liver pathology is limited to selected patients or unavailable. Therefore, we aimed to determine the prevalence and severity of liver fibrosis in an adult AATD population who were...
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