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Article

Meta-Analysis: Redefining Liver Disease Risk in Heterozygous Alpha-1 Antitrypsin Deficiency.

Alimentary pharmacology & therapeutics - 1 Aug 2026

Syanda Adam M, Georgantaki Dimitra, Linn Riona T T, Agbai Amara, Tahir Hassan, Sakai Manako, Thompson Richard, Molokhia Mariam, Rashid S Tamir

Abstract excerpt

BACKGROUND: Heterozygous SERPINA1 genotypes (MZ, SZ) have historically been regarded as carrier states with limited liver relevance. Emerging evidence suggests increased liver injury, but the magnitude of risk remains uncertain. We synthesized evidence on heterozygous SERPINA1 liver phenotypes to quantify this risk. METHODS: We performed a systematic review of bibliographic databases from inception to 21 October...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42437373
DOI: 10.1111/apt.70814
PMCID: PMC13419271

Genes

SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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