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Article

Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells.

Experimental & molecular medicine - 30 Jun 2006

Lee Eunmyong, Choi Moon Kyung, Han Inn Oc, Lim Soo Jeong

Abstract excerpt

SC-560, a structural analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells mainly by inducing cell cycle arrest, we sought to examine the role of p21CIP1, a cell cycle regulator protein, in the cellular response against SC-560 by using p21(+/+) and p21(-/-) isogenic HCT116 colon...

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Identifiers

PMID: 16819292
DOI: 10.1038/emm.2006.39

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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