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Article

Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin

15 Dec 2004

Abstract excerpt

BACKGROUND: Colon adenocarcinomas are refractory to a number of widely used anticancer agents. Multifactorial mechanisms have been implicated in this intrinsically resistant phenotype, including deregulation of cell death pathways. In this regard, the p53 protein has a well established role in the control of tumor cell response to DNA damaging agents; however, the relationship between p53-driven genes and drug...

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PMID: 15601469
DOI: 10.1186/1471-2407-4-92

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