Article
Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistance.
Cancer chemotherapy and pharmacology - 1 Jun 2011
Kalimutho Murugan, Minutolo Antonella, Grelli Sandro, Formosa Amanda, Sancesario Giulia, Valentini Alessandra, Federici Giorgio, Bernardini Sergio
Abstract excerpt
PURPOSES: Satraplatin acts as a potent inhibitor of proliferation in castration-resistant prostate cancer, yet the basic and molecular pharmacological mechanisms are still unknown in all types of cancer including colorectal cancer (CRC). In an effort to explain the mechanism of tumour sensitivity...
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