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Article

Cladosporol a stimulates G1-phase arrest of the cell cycle by up-regulation of p21(waf1/cip1) expression in human colon carcinoma HT-29 cells.

Molecular carcinogenesis - 1 Jan 2013

Zurlo Diana, Leone Cinzia, Assante Gemma, Salzano Salvatore, Renzone Giovanni, Scaloni Andrea, Foresta Caterina, Colantuoni Vittorio, Lupo Angelo

Abstract excerpt

Cladosporols, purified and characterized as secondary metabolites from Cladosporium tenuissimum, display an antifungal activity. In this study, we tested the antiproliferative properties of cladosporol A, the main isoform of this metabolite family, against human cancer cell lines. By assessing cell viability, we found that cladosporol A inhibits the growth of various human colon cancers derived cell lines (HT-29,...

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Source

Identifiers

PMID: 22025467
DOI: 10.1002/mc.20872

Genes

CDK2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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