Article
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications - 30 Sept 1991
Wisniewski T, Ghiso J, Frangione B
Abstract excerpt
beta-Amyloid (A beta) deposition in fibril form is the central event in a number of diseases, including Alzheimer's disease (AD) and hereditary cerebral hemorrhage with amyloidosis - Dutch type (HCHWA-D). A beta is produced by degradation of a larger amyloid precursor protein (APP). Recently a mu...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Peptides
- Glutamates
- Glutamic Acid
- Glutamine
- Microscopy, Electron
- Microscopy, Immunoelectron
- Molecular Sequence Data
- Mutation
- Myofibrils
- Peptides