Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid beta/A4 peptide.

doi:10.1016/0304-3940(93)90129-9

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Article

Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid beta/A4 peptide.

Neuroscience letters - 14 Oct 1993

Clements A, Walsh D M, Williams C H, Allsop D

Abstract excerpt

We assessed the fibrillogenic properties of synthetic peptides corresponding to residues 13-26 of beta/A4 amyloid, containing either the normal sequence (beta 13 26) or the mutations Glu22 to Gln (beta 13-26Q22) and Ala21 to Gly (beta 13-26G21). The kinetics of aggregation were monitored at 37 de...

Topics

Alanine
Alzheimer Disease
Amino Acid Sequence
Amyloid
Amyloid beta-Peptides
Glutamates
Glutamic Acid
Glycine
Humans
Molecular Sequence Data
Mutation

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