Article
Expression of a normal and variant Alzheimer's beta-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays.
Biochemical and biophysical research communications - 16 Jul 1990
Prelli F, Levy E, van Duinen S G, Bots G T, Luyendijk W, Frangione B
Abstract excerpt
Amyloid fibrils deposited in cerebral vessel walls in Dutch patients with hereditary cerebral hemorrhage with amyloidosis (HCHWA-D) are formed by polymerization of a 39-residue peptide similar to the beta-protein of Alzheimer's disease, Down syndrome, sporadic cerebral amyloid angiopathy and norm...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid
- Amyloid beta-Peptides
- Amyloidosis
- Base Sequence
- Cerebral Hemorrhage
- DNA
- Gene Expression
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction