Article
Oligomerization of beta-amyloid of the Alzheimer's and the Dutch-cerebral-haemorrhage types.
The Biochemical journal - 1 Jul 2000
Sian A K, Frears E R, El-Agnaf O M, Patel B P, Manca M F, Siligardi G, Hussain R, Austen B M
Abstract excerpt
A novel ELISA has been developed which detects oligomerization of beta-amyloid (A beta). Oligomerization, fibrillization and neurotoxicity of native A beta associated with Alzheimer's disease (AD) type has been compared with E22Q A beta (amyloid beta-protein containing residues 1--40 with the native Glu at residue 22 changed to Gln) implicated in Dutch cerebral haemorrhage disease. Solutions of A beta rapidly...
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