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Article

[Histological function of PTHrP in cartilage].

Clinical calcium - 1 Jul 2006

Li Minqi, Amizuka Norio

Abstract excerpt

Parathyroid hormone-related peptide (PTHrP) is known as an important local factor for chondrogenesis, promoting chondrocyte proliferation and inhibiting their differentiation into the hypertrophic phenotype. Signaling transduction through the PTH/PTHrP receptor has two possible pathways: the activation of adenylate cyclase and subsequent protein kinase A (PKA), and the activation of phospholipase C (PLC). Recent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16816485
DOI: CliCa060712211227

Genes

PTH
NHERF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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[Histological function of PTHrP in cartilage].PMID 16816485Read ↗

The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.Semantic proximity Read ↗

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Parathyroid Hormone Related Protein (PTHrP)-Associated Molecular Signatures in Cell Signaling during Tissue Differentiation and in Non-tumoral DiseasesSemantic proximity Read ↗

[Cytokines in bone diseases. Genetic defects of PTH/PTHrP receptor in chondrodysplasia].Semantic proximity Read ↗

Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation.Semantic proximity Read ↗

Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.Semantic proximity Read ↗

The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation.Semantic proximity Read ↗

Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice.Semantic proximity Read ↗

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Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse modelSemantic proximity Read ↗

Disruption of β-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation.Semantic proximity Read ↗

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