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Article

Differential activation of CYP2C9 variants by dapsone.

Biochemical pharmacology - 15 May 2004

Hummel Matthew A, Dickmann Leslie J, Rettie Allan E, Haining Robert L, Tracy Timothy S

Abstract excerpt

Studies have shown that CYP2C9.1 mediated metabolism of flurbiprofen or naproxen is activated by co-incubation with dapsone. However, dapsone activation has not been examined in the known variant forms of CYP2C9. Six concentrations of flurbiprofen (2-300microM) or naproxen (10-1800 microM) were co-incubated with six concentrations of dapsone (0-100 microM) and with reconstituted, purified CYP2C9.1, CYP2C9.2...

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Source

Identifiers

PMID: 15130760
DOI: 10.1016/j.bcp.2004.01.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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