Article
Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation.
Gene - 1 Sept 2006
Sato Toru, Endoh Mitsuhiro, Yoshida Hisahiro, Yasuo Suzuki, Katsuno Tatsuro, Saito Yasushi, Isono Kyo-ichi, Koseki Haruhiko
Abstract excerpt
The vertebrate Polycomb Group (PcG) genes encode proteins that form large multimeric and chromatin-associated complexes implicated in the stable repression of developmentally essential genes. Rnf110 and Phc2 are shown to be components of mammalian PcG multimeric complexes in HeLa cells. Here we report defects in Peyer's patch (PP) development in Rnf110 mutant mice, which is synergically exaggerated by Phc2...
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