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Article

NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity.

Arthritis research & therapy - 1 Jan 2006

Kawaguchi Yasushi, Tochimoto Akiko, Hara Masako, Kawamoto Manabu, Sugiura Tomoko, Katsumata Yasuhiro, Okada Jun, Kondo Hirobumi, Okubo Mitsuo, Kamatani Naoyuki

Abstract excerpt

Systemic sclerosis (SSc) is a connective tissue disease characterized by tissue fibrosis. One of several complications of SSc, pulmonary arterial hypertension (PAH) can be refractory to treatment, both novel and established. In the present study we investigated the ratio of circulating nitric oxide to endothelin-1 in patients with both SSc and PAH, and determined whether polymorphisms in NOS2 (the nitric oxide...

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Share to Endothelin-1
Share to Hypertension, Pulmonary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nitric Oxide

Share to Nitric Oxide Synthase Type II

Share to Osmolar Concentration

Share to Scleroderma, Systemic

Share to Tandem Repeat Sequences

Share to Transcription, Genetic

Source

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Identifiers

PMID: 16813666
DOI: 10.1186/ar1984
PMCID: PMC1779390

Genes

PAH
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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