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Article

Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies.

The Biochemical journal - 15 Nov 2006

Di Luccio Eric, Elling Robert A, Wilson David K

Abstract excerpt

The AKRs (aldo-keto reductases) are a superfamily of enzymes which mainly rely on NADPH to reversibly reduce various carbonyl-containing compounds to the corresponding alcohols. A small number have been found with dual NADPH/NADH specificity, usually preferring NADPH, but none are exclusive for NADH. Crystal structures of the dual-specificity enzyme xylose reductase (AKR2B5) indicate that NAD+ is bound via a key...

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Identifiers

PMID: 16813561
DOI: 10.1042/BJ20060660
PMCID: PMC1635432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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